CALL FOR PAPERS Renal Hemodynamics Attenuating effect of angiotensin-(1–7) on angiotensin II-mediated NAD(P)H oxidase activation in type 2 diabetic nephropathy of KK-A/Ta mice
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چکیده
Ju-Young Moon, Mitsuo Tanimoto, Tomohito Gohda, Shinji Hagiwara, Takahiko Yamazaki, Ikko Ohara, Maki Murakoshi, Tatsuya Aoki, Yuji Ishikawa, Sang-Ho Lee, Kyung-Hwan Jeong, Tae-Won Lee, Chun-Gyoo Ihm, Sung Jig Lim, and Yasuhiko Tomino Division of Nephrology, Department of Internal Medicine, Juntendo University Faculty of Medicine, Tokyo, Japan; Division of Nephrology, Department of Internal Medicine, and Department of Pathology, Kyung Hee University Hospital at Gangdong, Seoul; and Division of Nephrology, Department of Internal Medicine, Kyung Hee University, Seoul, Korea
منابع مشابه
AT2R agonist, compound 21, is reno-protective against type 1 diabetic nephropathy.
The hemodynamic and nonhemodynamic effects of angiotensin II on diabetic complications are considered to be primarily mediated by the angiotensin II type 1 receptor subtype. However, its biological and functional effect mediated through the angiotensin II type 2 receptor subtype is still unclear. Activation of the angiotensin II type 2 receptors has been postulated to oppose angiotensin II type...
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Glucagon-like peptide-1 (GLP-1) is a gut incretin hormone that has an antioxidative protective effect on various tissues. Here, we determined whether GLP-1 has a role in the pathogenesis of diabetic nephropathy using nephropathy-resistant C57BL/6-Akita and nephropathy-prone KK/Ta-Akita mice. By in situ hybridization, we found the GLP-1 receptor (GLP-1R) expressed in glomerular capillary and vas...
متن کاملLessons From the KK-Ay Mouse, a Spontaneous Animal Model for the Treatment of Human Type 2 Diabetic Nephropathy
Diabetic nephropathy is a major cause of end-stage kidney disease (ESKD) in patients with type 1 and type 2 diabetes throughout the world. In human glomeruli, expansion of diffuse mesangial matrices, exudative lesions and/or segmental nodular sclerosis are pathological features of diabetic nephropathy. There have been many reports on the pathogenesis and treatment of type 2 diabetes using vario...
متن کاملMas-Mediated Antioxidant Effects Restore the Functionality of Angiotensin Converting Enzyme 2-Angiotensin-(1–7)-Mas Axis in Diabetic Rat Carotid
We hypothesized that endothelial AT1-activated NAD(P)H oxidase-driven generation of reactive oxygen species during type I-diabetes impairs carotid ACE2-angiotensin-(1-7)-Mas axis functionality, which accounts for the impaired carotid flow in diabetic rats. We also hypothesized that angiotensin-(1-7) chronic treatment of diabetic rats restores carotid ACE2-angiotensin-(1-7)-Mas axis functionalit...
متن کاملEfficacy of pentoxifylline for reduction of proteinuria in type II diabetic patients
Background: Diabetic nephropathy is considered to be the most common cause of end stage renal disease (ESRD). Proteinuria is declared as the most marked risk factor in progression towards ESRD. The aim of this study was to evaluate the efficacy of pentoxifylline for reduction of proteinuria in type II diabetic patients. Methods: From May 2007 to June 2008, this randomized clinical trial study w...
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تاریخ انتشار 2011